Radiation therapy is one of the main methods for the treatment of tumors at present, through downregulating the expression of Notch-, Jagged1/2, Hey-1 and Hes-1, downregulating the expression of miR-410, causing attenuated invasion and migration in GC cells; tangeretin greatly enhanced the radiosensitivity of GC cells [143]. Here, HES1 is linked to gastric cancer.