PIK3CA and neoplasm: Inhibition of colon cancer by hesperidin involves multiple alterations, including caspase-3-mediated apoptosis, the autophagy program initiated by PI3K/Akt/GSK-3c and mTOR pathway and, down-regulation of NF-κB and its target molecules iNOS and COX-2 to attenuate oxidative stress and enhance antioxidants to fight tumor-induced inflammation [147,148,149,150].