PIK3CD and posterior cortical atrophy: In addition, Tanshinone has been reported to be significantly associated with the down-regulation of astrocyte elevating gene 1 (AEG-1) in PCa cells [31], which is involved in the regulation of multiple signaling pathways in cancer cells, including PI3K/Akt, NF-κB, Wnt/-catenin, and MAPK.