Secondly, in a clinical trial, LinTH et al. found that although the use of enzaluamide and bicaluamide could lead to the reduction of the primary tumor and PSA, the invasion of PCa cells was significantly enhanced, while the use of Tanshinone could not only achieve the reduction of the primary tumor and PSA but also inhibit PCa cell invasion to a certain extent [53]. This evidence concerns the gene KLK3 and posterior cortical atrophy.