As the report goes, Tanshinone activates mitochondrial-dependent apoptosis of PCa cells by inhibiting the expression of mitochondrial protective Bcl-2 family protein Mcl-1 by inducing the cleavage of ADP ribose polymerase (PARP), promoting the release of cytochrome c from the mitochondria to the cytoplasm and reducing mitochondrial membrane potential. Here, PARP1 is linked to posterior cortical atrophy.