AKT1 and Familial prostate cancer: In addition, Tanshinone has the pharmacological effect of promoting the expression of phosphatase and tensin homologue (PTEN), a negative regulatory gene of PI3K [133,154,155], which negatively regulates PI3K Akt mTOR signal transduction by transforming PIP3 back to PIP2 [156] and the deletion of this gene usually occurs with the progression of prostate cancer [157,158].