In the experiments conducted by Wang et al., they found that Tanshinone derivatives induce PCa cell apoptosis by regulating p53, ERK1, BAX, P38, Bcl-2, caspase-8, cleavedcaspase-8, and PARP1, and significantly affect the phosphorylation of ERK1 and P38 in P38 [54]. This evidence concerns the gene MAPK3 and posterior cortical atrophy.