Second, Tanshinone has been shown to induce ER stress pathway apoptosis in PCa cells by increasing the expression of key proteins of ER stress pathway apoptosis, such as glucose regulatory protein 78 (BIP/GRP78), ER stress sensor (IRE1-) and its downstream target CAAT/enhancer binding protein homologous protein/growth arrest and DNA-damage-inducing gene 153 (gadd153/cho) [48,53]. Here, HSPA5 is linked to posterior cortical atrophy.