TNFRSF10B and posterior cortical atrophy: In addition, Tanshinone has been shown to be an effective sensitizer of tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) to enhance TRAIL-mediated apoptosis, which seems to be related to Tanshinone activation of mir135A-3p mediated up-regulation of death receptor 5 (DR5) in PCa cells [52].