A dual modal PAI and photothermal imaging probe rGADA nanocomposite was fabricated by the rGO functionalized with AuNS (gold nanostars), bilayered lipids, FA (rGADA), and K-Ras gene plasmid (KrasI) rGADA-KrasI, for targeted imaging guided photothermal and gene therapy of pancreatic cancer. This evidence concerns the gene KRAS and familial pancreatic carcinoma.