Notably, SAMP8 mice exhibit many features that occur early in the pathogenesis of aging-related AD, such as oxidative stress, β-amyloid and α-synuclein accumulation, tau hyperphosphorylation, neurofibrillary tangles, gliosis, and cell death, and impairments in learning and memory [18,19,22,23,24,25]. Here, MAPT is linked to Alzheimer disease.