PRKN and myocardial ischemia: When myocardial ischemia happens, Parkin and FUN14 domain-containing protein 1(FUNDC1)-mediated mitochondrial autophagy can specifically eliminate dysfunctional mitochondria, reduce their digestion of ATP, and increase the threshold of open healthy mitochondrial permeability transition pore (mPTP) in cardiomyocytes, thereby exerting myocardial protection [38,39].