They found that activation of the Wnt/β-catenin pathway and the overexpression of several enzymes from the ubiquitin-proteasome system (namely E3 ligases) as well as autophagy-related enzymes (such as cathepsin L and sequestosome 1) were commonly observed in patients with cancer or kidney failure, suggesting that the degradation of the muscle contractile function and the cytoskeleton integrity may be similar, irrespective of the underlying pathological condition. Here, CTSL is linked to cancer.