String bioinformatic mapping of exosome-associated differentially abundant proteins determined statistical associations with complement and coagulation cascades (CCC, pathway code HSA04610, 24 proteins), platelet degranulation (PD, pathway code HSA-114608, 14 proteins) and cholesterol metabolism (CM, pathway code HSA04979, four proteins) pathways and thrombotic diseases-gene associations factors (TF, DOID:2364 and DOID:10772, four proteins), (Table 2). The gene discussed is TF; the disease is thrombotic disease.