The compound SHP-D26 potently degrades the SHP2 protein in esophageal cancer KYSE520 and acute myeloid leukemia (AML) MV4; the 11-cell line, with a half-maximal degradation concentration (DC50) of 6.0 and 2.6 nM, respectively. The gene discussed is PTPN11; the disease is acute myeloid leukemia.