EGFR and neoplasm: Tumor-promoting factors such as interleukin-6 (IL-6), IL-10, IL-11, vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) bind to their corresponding receptors, stimulating the phosphorylation of Janus kinases (JAK), receptor tyrosine kinases (such as EGFR) and non-receptor tyrosine kinases (such as breakpoint cluster region-abelson [Bcr-Abl]) [152,154].