Moreover, in bladder cancer cell lines (253J-Bv and T24), co-treatment of curcumin (10 M) and cisplatin (10 M) stimulated caspase-3 and overexpressed phospho-mitogen-activated protein kinase (p-MEK) and phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2) signaling pathways [44]. The gene discussed is MAPK3; the disease is urinary bladder cancer.