Although the redox-sensitive nuclear transcription factor NF-κB in the intestine is involved in maintaining intestinal epithelial cell homeostasis and modulating intestinal permeability [4], the chronic activation of NF-κB is typical of IBD and may play an important role in the exacerbation of inflammation of the intestinal epithelium [5,6,7]. Here, NFKB1 is linked to inflammatory bowel disease.