Fiber may help regulate the gut microbiota and glucose metabolism and further enhance insulin resistance in the brain [71]; B-vitamins may assist in regulating energy by supplying homocysteine metabolism [74]; vitamins C and E may provide antioxidant properties [73]; and vitamin D may be involved in the regulation of neurotransmitters and neurotrophin and may have anti-inflammatory and antioxidant neuroprotective capacities [75]. Here, BDNF is linked to Insulin resistance.