As for the differentially expressed proteins in colostrum compared with mature milk, the main participating pathways were metabolic pathways, the PI3K-Akt signaling pathway, and the NF-kappa B signaling pathway, whereas in colostrum, compared with transitional milk, the main pathways were the PI3K-Akt signaling pathway, Epstein-Bar virus infection, and systemic lupus erythematosus, as shown in Figure 5D–F. Here, AKT1 is linked to systemic lupus erythematosus.