BAX and leukemia: Moreover, several reports indicate that phloretin possesses anticancer effects against several other cancer cells, including K562 leukemia cells, HL60 human leukemia cells, B16 melanoma, colon cancer cells, and hepatoma cell line via various cellular mechanisms such as arresting cell cycle, inducing apoptosis, activating of Bax and caspase expression, downregulating matrix metalloproteinase (MMP) expression, and reducing the occurrence of oxidative stress [6,7,88,89,90].