KEAP1 and experimental autoimmune encephalomyelitis: In the experimental autoimmune encephalomyelitis model, phloretin suppressed neuroinflammation via activation of Nrf2 signaling in macrophages, which occurs due to 5′ AMP-activated protein kinase (AMPK)-dependent activation of autophagy and consequent degradation of kelch-like ECH-associated protein 1 (Keap1) [24].