Improved histopathological changes in the colon of mice with dextran sulfate sodium-induced ulcerative colitis;Inhibited TNF-α, IL-1β, IL-12 IL-17A and IFN-γ levels;Activation of NF-κB pathway, increased TLR4 expression, and reduced PPARγ expression in ulcerative colitis were restored;Escherichia coli and Lactobacillus levels were re-balanced. This evidence concerns the gene TLR4 and ulcerative colitis.