Reduced levels of BUN, UACR, tubular necrosis, ECM deposition, and interstitial fibroblasts in mice with hyperuricemia-induced renal dysfunction;Reduced renal inflammatory cells infiltration, cytokines (NLRP3 and IL-1β), mitochondrial ROS, and morphological lesions;Inhibited renal GLUT9 and promoted urinary uric acid excretion. Here, NLRP3 is linked to hyperuricemia.