Improved motor performance of animals with Parkinson’s disease-like condition induced by MPTP;Increased dopamine levels and tyrosine hydroxylase enzyme expression;Suppressed neuroinflammation: reduced expression of GFAP, iba1, iNOS and COX2;Reduced levels of proinflammatory cytokines (IL-β, IL-6, and TNF-α). The gene discussed is AIF1; the disease is Parkinson disease.