In HEK293 cells transiently transfect with ORM (yeast)-Like protein isoform 3 (ORMDL3) mRNA expression, an asthma susceptibility gene [75], BHB controlled inflammation inhibiting ER stress response pathway proteins and enhancing both Foxp3 and manganese superoxide dismutase (MnSOD) transcription via AMP-activated protein kinase (AMPK) activation, leading to a decrease in cellular oxidative stress [76]. The gene discussed is SOD2; the disease is asthma.