Significant increases in serum blood urea nitrogen (BUN), creatinine, aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were observed in the OVX control group compared with that in the sham control group, indicating that diseases of the liver and kidneys occurred through the induction of osteoporosis. The gene discussed is GPT; the disease is medical procedure.