Other than causing liver abnormality, Vasn deficiency in C57BL/6J mice also induced abnormalities in myocardial structure and myocardial disorders, which are important pathological features of cardiac hypertrophy (as shown in our previous study) [14], and both can be key causes responsible for the weight loss and the premature death of Vasn KO mice, which are complicated and ambiguous. The gene discussed is VASN; the disease is myocardial disorder.