VASN and glucose metabolism disease: In this study, starting from the initial discovery of weight loss and life span shortening as the unexpecting biological problems of Vasn KO mice, we found the association of liver injury and liver glycogen depletion at the macroscopic histology level, followed by the potential involvement of mTOR pathway-mediated hepatocyte autophagy in glucose metabolism disorder of the liver at the microscopic cellular biology and molecular mechanism levels.