Previous studies suggested the potential mechanisms as follows: central obesity may be linked to platelet dysfunction by inducing the alteration of intracellular ionic milieu, decreasing sensitivity to insulin and other substances that function through intracellular cyclic nucleotides, and increasing oxidative stress, and finally contributing to accelerated aging reflected by telomere and mitochondrial dysfunction [50,51,52,53]. This evidence concerns the gene INS and Abdominal obesity.