In contrast, and at variance with our previous finding that expression of cytokine proteins such as IL-8, MCP-1, GRO, GROα, IL-2 and IL-3 was enhanced with magnesium deficiency [14], the array analysis found little impact of low magnesium on interleukins and their associated signaling pathway. The gene discussed is CXCL8; the disease is magnesium deficiency.