In particular, several studies point to the role of EVOO in maintaining mitochondrial homeostasis through modulation of Sirt1 and PGC1-α expression (Figure 4), and this data appears extremely interesting, especially in light of the fact that accumulation of dysfunctional mitochondria is a major contributing factor to the development of sarcopenia [133,134,135]. The gene discussed is PPARGC1A; the disease is sarcopenia.