INS and type 2 diabetes mellitus: Alternatively, different anti-diabetic drugs approved by the Food and Drug Administration (FDA) [8] (e.g., biguanides (metformin), inhibitors of glucose absorption (SGLT2 inhibitors, acarbose), glitazones (PPARγ agonists), modulators of incretin (DPP-IV inhibitors and GLP-1 receptor agonists), insulin secretagogues (sulphonylureas), etc.)can be used alone or in combination to moderate the progression of T2DM.