INS and type 2 diabetes mellitus: Data from many studies infer both correlative and causative association between higher activity of proinflammatory processes in adipose tissue and impaired insulin metabolism, insulin resistance, and type 2 diabetes [48]; thus, in obese individuals, there is a predominance of pro-inflammatory processes that causes systemic low-grade chronic inflammation that appears to not be present in non-obese and non-insulin resistant PCOS subjects.