Therefore, the objective of this study was to investigate the effect of date fruit on HbA1c and its variability, fasting blood glucose and its variability, insulin resistance (IR), insulin sensitivity (IS), beta cell function, and the cardiovascular risk indices of C-Reactive Protein (CRP) and fasting lipids in patients with T2D in comparison to raisins that have the same glycemic load. This evidence concerns the gene INS and Insulin resistance.