INS and hyperinsulinism: Insulin resistance in adolescents is characterized by a reduced insulin sensitivity, followed by compensatory hyperinsulinemia in order to maintain an euglycemic state [1], and it increases the likelihood of some conditions such as glucose intolerance, dyslipidemia, endothelial dysfunction, procoagulant factors, hemodynamic changes, markers of inflammation, increased testosterone secretion, and sleep-disordered breathing [2].