CRP and nutritional deficiency disease: On the other hand, we also compared healthy adult controls and found that, although more than 90% of patients had an ECOG PS ≤1 before CCRT, they still had significant reductions in BW, BMI, serum levels of essential amino acids (histidine, leucine, and phenylalanine), were more likely to develop malnutrition status, and presented with higher inflammation severity (indicated by advanced GPS and elevated CRP levels).