These include old age [14], comorbidity [14,15], poor performance status [13,14], low body mass index (BMI) and body weight (BW) [13,14,16], anemia [14,15], low total lymphocyte count [13], low prognostic nutritional index (PNI) [17], high levels of C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) [18,19,20], and total muscle and fat mass [19,21]. The gene discussed is CRP; the disease is anemia (phenotype).