Patients with LAHNSCC showed significantly higher malnutrition rates compared to the control group participants according to the different criteria (BWL > 5.0%: 26.0% vs. 2.3%, p = 0.001; BMI < 18.5 kg/m2: 18.0% vs. 0.0%, p = 0.003; TLC < 1.5 × 103 cells/mm3: 34.0% vs. 14.0%, p < 0.001; albumin < 3.5 g/dL: 14.0% vs. 0.0%, p < 0.001), advanced GPS (GPS 1 + 2: 34.0% vs. 2.3%, p = 0.001), and displayed a more severe inflammatory status (CRP > 5 mg/L: 34.0% vs. 2.3%, p = 0.001). The gene discussed is ALB; the disease is malnutrition.