In this study, based on the detection of the main components of IH, combined with gut microbiota and lipid metabolomic analyses, the role of IH in regulating oxidative stress and inflammation, based on the Nrf2/NF-κB signaling pathway, to alleviate obesity symptoms was explored in C57BL/6 mice with DIO. Here, NFE2L2 is linked to obesity due to melanocortin 4 receptor deficiency.