The Western blot and real-time PCR findings exhibited that the combination therapy reduced the expressions of Fzd7, Nedd9, VEGF-α, Vim and Mmp9 and upregulated E-Cad in 4T1 cells and liver and tumor tissues, thus preventing Wnt/β-catenin signaling and averting metastasis in TNBC [96]. The gene discussed is FZD7; the disease is neoplasm.