In addition, as holistic medicine, the anti-migraine mechanism of ALHP possibly acts through the NF-kappa B, TNF, cAMP, HIF-1, Toll-like receptor, and calcium signaling pathways to moderate the neurovascular systems and through neuro-inflammation and pain-related proteins, which produces a synergistic effect to relieve the burden of migraines. This evidence concerns the gene TNF and migraine disorder.