The findings showed that ALHP exerts a potential role in treating migraines by regulating multiple target genes, including ACE, SLC6A3, NR3C1, HTR2A, HTR2C, GRIN1, GRIN2A, DRD2, MAPK1, IL1B, RELA, NOS2, and PIK3CA. This evidence concerns the gene IL1B and migraine disorder.