On the other hand, Fernández-Ponce et al. [7] determined its cytotoxic effect in breast cancer cell lines, attributing their results to the synergistic effects of the different polyphenols, such as mangiferin, gallotannins, methyl gallate and homomangiferin, present in the extract, while Abdullah et al. [8] studied the anticancer effect of mango seed extract and of mango kernel on estrogen-receptor-positive human breast carcinoma cells (MCF-7), determining that the extract induced apoptosis of cancer cells through the activation of oxidative stress. Here, ESR1 is linked to breast carcinoma.