According to the European Association for the Study of the Liver (EASL) guidelines [2], at least two of the following three criteria must be met for confirming a diagnosis of PBC: (1) serum AMA and/or ANA positivity, (2) cholestatic pattern of liver biochemistry tests with at least one increased value among serum bilirubin, ALP, or gamma-glutamyltransferase (GGT), or (3) diagnostic liver histology. Here, BTG3 is linked to primary biliary cholangitis.