Hydrophilicity, negative charge, and anticoagulant mechanism of action.Reduced protein (both fibrinogen and albumin) and bacterial adhesion; reduction in inflammatory markers; reduction in bleeding events; mimicking endothelium; negative charge dependent platelets repletion and inhibition of thrombin; preserved platelet count; increases the stroke rate in cardiopulmonary bypass; evidence from small and single center studies, missing long-term evaluation. Here, ALB is linked to Stroke.