IRS1 and metabolic dysfunction-associated steatotic liver disease: An Interesting link between IR and NAFLD is defined by the presence of certain genes, such as ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1 121 Gln) and the Insulin Receptor Substrate-1 (IRS-1) 972 Arg polymorphism that decreases the activity of protein kinase B (AKT) of the insulin receptor in hepatocytes [31].