Some real-world population studies on older adults with T2DM have consistently shown that, despite the fact that they are well controlled (HbA1c < 7%), they are treated with antidiabetic drugs associated with a high risk of hypoglycemia (insulin, sulfonylureas, and glinides) and, thus, they might be at risk of overtreatment [12,13,14,15,16,17,18]. This evidence concerns the gene INS and type 2 diabetes mellitus.