Although the number of mutations in individual genes are low, when colorectal cancers are categorized according to BRAF and PIK3CA mutations, the prevalence of oncogenic or likely oncogenic mutations in these genes as a whole is higher in colorectal cancers with both BRAF and PIK3CA wild type (63.4%) than in double mutant cancers (47.3%) or cancers with BRAF mutated and PIK3CA wild type (41.7%) and with PIK3CA mutant and BRAF wild type (49.8%, χ2 p < 0.001, Table 5). The gene discussed is PIK3CA; the disease is cancer.