PIK3CA and colorectal cancer: However, in the DFCI cohort, although double BRAF and PIK3CA wild type colorectal cancers have a numerically higher prevalence of oncogenic/likely oncogenic mutations in commonly mutated cancer-associated genes (53.8%), the differences from the three other groups (BRAF or PIK3CA mutated or both mutated) were small and borderline statistically insignificant (χ2 p = 0.051, Table 6).