Tumor suppressor FBXW7 and ATM mutations are more common in BRAF mutant cancers with or without PIK3CA mutations than in BRAF wild type colorectal cancers (Fisher’s exact test p = 0.0004 for FBXW7 and p < 0.0001 for ATM in TCGA and Fisher’s exact test p = 0.0003 for FBXW7 and p < 0.0001 for ATM in the DFCI cohort, Figure 2). The gene discussed is PIK3CA; the disease is cancer.