In this context, we aimed to investigate the role of intestinal permeability biomarkers in relation to depression in patients with inflammatory bowel disease (IBD) by (i) examining the relationship between calprotectin, zonulin, LBP, IFABP/FABP2 and depression and by (ii) evaluating the influence of depression on the quality of life. The gene discussed is LBP; the disease is depressive symptom measurement.