In this context, we aimed to investigate the role of intestinal permeability biomarkers in relation to depression in patients with inflammatory bowel disease (IBD) by (i) examining the relationship between calprotectin, zonulin, LBP, IFABP/FABP2 and depression and by (ii) evaluating the influence of depression on the quality of life. Here, FABP2 is linked to inflammatory bowel disease.