AFP and hepatocellular carcinoma: In particular, the AUC of PIVKA-II in diagnosing HCV-induced HCC was 0.900 (0.852–0.937), which was significantly better than the performances of AFP alone (0.802 [0.743–0.853]; p = 0.008) or AFP-L3 alone (0.688 [0.630–0.742]; p < 0.001) (Figure 2C).