In turn, other HCC-specific serum biomarkers, including prothrombin induced by vitamin K absence-II (PIVKA-II, i.e., des-gamma-carboxy prothrombin) and lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3) have been proposed and investigated [21,22,23]. Here, AFP is linked to hepatocellular carcinoma.