The observed concentration profile of the assessed ECM remodeling markers, i.e., GAAGs, COMP, and YKL-40, in biologically treated children with JIA seems to indicate that COMP and YKL-40 may be useful biomarkers of the disease course, assessment of treatment efficacy, and long-term periodic follow-up after completion of therapy for early detection of possible arthropathy recurrence. The gene discussed is CHI3L1; the disease is juvenile idiopathic arthritis.