Figure 3 shows a 18F-PSMA with a histopathologically confirmed aggressive PC with a GS of 8 (4 + 4), without locoregional LNM and without skeletal metastases, but with three mediastinal LNM of normal size, located infracarinally and bilaterally hilar with a high PSMA avidity, and Figure 4 shows a 68Ga-PSMA with a histopathologically confirmed aggressive PC with a GS of 8 (4 + 4) with locoregional LNM and without distant LNM and without skeletal metastases. The gene discussed is FOLH1; the disease is pachyonychia congenita.