The signals of disproportionate reporting (SDRs) for DPP-4 inhibitors were detected in major cardiovascular events (IC: 0.22, 95% credible interval: 0.03–0.40), and in the AEs of myocardial infarction (IC: 1.21, 95% credible interval: 0.87–1.55), and heart failure (IC: 0.40, 95% credible interval: 0.17–0.63). This evidence concerns the gene DPP4 and heart failure.