However, Lee et al. argued that coagulopathy did not exist in East Asian patients because no differences were found in the thrombotic factors (protein C, protein S, antithrombin III, anticardiolipin antibody, and lupus antibody) and the fibrinolytic factors (tissue plasminogen activator, plasminogen activator inhibitor-1, lipoprotein (a), and plasminogen) in 24 ONFH patients and 24 matched controls [11]. This evidence concerns the gene PROS1 and blood coagulation disease.