Consistently, an association was found between LH shape during contraction and UI severity at follow-up (average increase of 2.7 points in incontinence severity [ICIQ-UI SF] per unit increase in LH shape ratio on contraction, 95% confidence interval 0.3 to 5.0, p = 0.03), where women with a smaller and more circular shaped LH presented lower UI symptoms. This evidence concerns the gene PLOD1 and Urinary incontinence.