For the association between highly exposed participants to PM2.5 (i.e., with an exposure higher than 12 μg/m3, US EPA guidelines) five and ten years before cancer diagnosis and TP53 mutation, the adjusted ORs (95% CI) were 1.61 (0.95, 2.73) and 1.57 (0.93, 2.64), respectively (Figure 2). This evidence concerns the gene TP53 and cancer.