Moreover, it seems that the inflammatory profile at IRCU admission is linked to worse outcomes as pointed out in many previous studies [26,27]; we observed that specifically higher levels of D-dimer [6,28] and CRP [29,30] are the most relevant biomarkers with potential usefulness as biomarkers of COVID-19 severity, although their efficacy in predicting treatment response is still inconclusive [31,32]. The gene discussed is CRP; the disease is COVID-19.