Moreover, Wang et al. [43] showed that S100A4 was required in a LASP1 mediated TGFβ1 induced EMT process in human colorectal cancer, while depletion of S100A4 suppressed the phosphorylation status of MEK, ERK, AKT, and Smad2, which indicates that S100A4 plays a key role in TGF-β1 induced cell invasiveness. This evidence concerns the gene AKT1 and colorectal cancer.