Taken together, these results demonstrate that the inactivation of the MEK/ERK and JAK2/STAT5 pathways via FLT3 inhibition plays a role in the transcriptional downregulation of c-Myc and the synergistic induction of apoptosis by combined FLT3 inhibition and Mcl-1 inhibition in FLT3-mutated AML cells. This evidence concerns the gene JAK2 and acute myeloid leukemia.