Interestingly, we found that AZD5991 and gilteritinib or MRX-2843 also synergize in inducing apoptosis in FLT3-wt AML cell lines and primary patient samples (Figures S1 and S2), which is likely due to the expression of wt-FLT3, AXL and/or MERTK in these cells (Figure S1). The gene discussed is FLT3; the disease is acute myeloid leukemia.