Elevated LACTB expression is correlated with malignant behaviors and poorer survival of with multiple types of malignancies in nasopharyngeal carcinoma;LACTB expression is upregulated in high-metastatic nasopharyngeal carcinoma cells with reduced methylation in the promoter region;Overexpressing LACTB in the nasopharyngeal carcinoma cells promotes motility in vitro and metastasis in vivo, and knock-down of LACTB reduces metastasis of nasopharyngeal carcinoma cells;LACTB does not influence the proliferation of nasopharyngeal carcinoma cells. Here, LACTB is linked to nasopharyngeal carcinoma.