LACTB expression is lower in colorectal cancer tissue than that in the adjacent tissue;LACTB is associated with clinical stage in colorectal cancer;LACTB expression is lower in the colorectal cancer patients with lymph node metastasis than those without lymph node metastasis;Low LACTB expression is associated with a lower 5-year survival rate in colorectal cancer patients compared to those with high LACTB expression. The gene discussed is LACTB; the disease is metastatic malignant neoplasm in the lymph nodes.