LACTB activates Erb-B2 receptor tyrosine kinase 3/Epidermal growth factor receptor-extracellular signal-regulated kinase signaling, promoting the metastasis of nasopharyngeal carcinoma;Suppressing LACTB reduced nasopharyngeal carcinoma cellular motility by enhancing histone H3 stability and its acetylation. Here, ERBB3 is linked to nasopharyngeal carcinoma.