LACTB expression is low in melanoma tissues and cell lines;Low LACTB expression is correlated with short survival time in melanoma patients;Overexpressing LACTB suppresses the proliferation, migration, and invasion of melanoma cells in vitro;Overexpressing LACTB induces cell apoptosis and cell cycle arrest at the G2/M phase;Overexpressing LACTB suppresses the tumorigenicity and lung metastasis of MUM2B uveal melanoma cells in vivo. Here, LACTB is linked to melanoma.