LACTB expression is downregulated in colorectal cancer;LACTB is associated with metastasis and advanced clinical stage;Low LACTB expression is associated with poor overall survival;Ectopic LACTB expression suppresses colorectal cancer cells proliferation, migration, invasion, and epithelial-to-mesenchymal transition in vitro, while knockout of LACTB results in an opposite phenotype;Ectopic LACTB expression inhibits colorectal cancer growth and metastasis in vivo, while knockout of LACTB results in an opposite phenotype. This evidence concerns the gene LACTB and colorectal cancer.