MAPT and Alzheimer disease: Our previous studies modeled noise exposure by simulating an industrial work environment with a duration of 4 h/day and showed that noise exposure is associated with cognitive decline as well as irreversible Alzheimer’s disease (AD)-like pathologies, such as hyperphosphorylated tau protein, amyloid-β (Aβ) accumulation, neuroinflammatory changes, and even neuronal apoptosis [7,8,9,10].