In this research, we verified that around-the-clock noise exposure can induce a string of functional autophagic flux disruptions and AD-like neuropathology in the cortex and the hippocampus of rats; these include abnormalities in AMPK-mTOR signaling and autophagosome–lysosome fusion, accumulation of APs related to amyloid pathology, tau hyperphosphorylation, and neuroinflammation. Here, CLOCK is linked to Alzheimer disease.