Furthermore, it has been demonstrated that the N-cadherin prodomain at the cell surface is a potential biomarker of pathological myofibroblasts and fibrosis in many tissues [24], and that TGF-β derived from colon cancer cells could induce N-cadherin expression, which consequently promoted invasion of myofibroblasts [23]. Here, TGFB1 is linked to malignant colon neoplasm.