The acknowledged neuropathological hallmarks of AD include extracellular senile plaques, composed of amyloid-beta (Aβ) peptides, and intracellular neurofibrillary tangles (NFTs) generated by the hyper-phosphorylated form of the tau protein, as well as selective neuronal and synaptic loss in specific brain regions. This evidence concerns the gene MAPT and Alzheimer disease.