Overall, given the conserved participation of TUBGCP2 homologs in molecular microtubule nucleating machineries, both our own data derived from the zebrafish and fruit fly systems and other available zebrafish data strongly support mitotic disruption and/or proliferative disorder of progenitor brain cells as key mechanistic defects linked to aberrant microtubule nucleation activities underlying human microcephaly. Here, TUBGCP2 is linked to microcephaly.