In cultured VSMCs, treatment with PGE1-OH or infection of Ad-EP4 also significantly upregulated the mRNA levels of genes related to cell proliferation including Ki67, Foxm1, Ccna2, Ccnb1, Ccnd1, Ccnd2, Ccne1, and CDK2 (Figure S4C,D). The gene discussed is CCND2; the disease is infection.